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Effectiveness of aloe vera in patients with type 2 Diabetes Mellitus and pre-diabetes: An overview of systematic reviews.

Rehabilitation in Health Research Center (CIRES), Universidad de las Americas, Santiago, Chile. Electronic address: fandres.kine@gmail.com. Faculty of Rehabilitation Sciences, Universidad Andres Bello, 7591538, Santiago, Chile. Therapeutic Process Department, Faculty of Health Sciences, Temuco Catholic University, Temuco, Chile. Facultad de Medicina Veterinaria y Agronomía, Universidad de las Américas, Santiago, Chile; Departamento de Ciencias Químicas y Biológicas, Universidad Bernardo O'Higgins, Santiago, Chile.

Diabetes & metabolic syndrome. 2021;(6):102292
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Abstract

BACKGROUND AND AIMS The effects of aloe vera are inconsistent and unclear. The aim of this study is to analyze the effects of aloe vera in metabolic profiles. METHODS An electronic search of systematic reviews (SRs) was performed in seven databases up to June 2021. RESULTS Four SRs met the eligibility criteria. In T2DM, SMD for FBG = -5.61 (p < 0.001). For HbA1c, MD = -0.95 (p = 0.02). In pre-diabetes, SMD for FBG = -1.41 (p = 0.02). For HbA1c, MD = -0.31 (p = 0.02). For TG, MD = -4.99 (p = 0.000). CONCLUSION There exist a moderate to high quality of evidence in favor of the effects of aloe vera in patients with T2DM and pre-diabetes.